The Margaret Pyke Trust works in both the health and environmental conservation sectors. This enabled the Trust to launch the Thriving Together campaign and bring together organisations working in both human health and environmental health.

The Trust has been a leader in contraception for 50 years and provides the broadest range of sexual and reproductive health training courses for UK clinicians. The Trust is a Family Planning 2020 (FP2020) Commitment Maker. FP2020 is a United Nations led global partnership composed of governments, civil society, multilateral organisations, donors, the private sector, and the research and development community with the aim of enabling 120 million more women and girls to use contraceptives by 2020. The Trust is an ally of Women Deliver, a member of the Uganda UK Health Alliance, and has representation on the Steering Group of the UK Sexual and Reproductive Health and Rights Network.

Uniquely, for an NGO with such a background, the Trust is also a Member of the International Union of the Conservation of Nature, has Observer Status with both the United Nations Framework Convention on Climate Change and United Nations Environment Programme, and is a member of the Bridge Collaborative and Planetary Health Alliance.